However, there aren't many studies that examine the use of CBD in treating chronic pain in people. The studies that do exist almost always include THC. This makes it hard to isolate CBD's unique effects.
For the study, 57 men took either CBD oil or a placebo (sugar pill) before a public-speaking event. The researchers based anxiety levels on measures like blood pressure and heart rate. They also used a fairly reliable test for mood states called the Visual Analog Mood Scale (VAMS).
It would be hard to overdose on CBD oil because human tolerance is very high. One study reported the toxic dose would be about 20,000 mg taken at one time.
Common side effects include:
The way that CBD acts in the brain can explain why this happens. In low doses, CBD may act the same as surrounding molecules that normally bind to the receptor, which "turns up" their signaling.
Studies found evidence, although not high-quality, that cannabis-based medicines reduced long-term nerve (chronic neuropathic) pain. All but two studies used plant-based THC/CBD mouth spray products (the other two used synthetic oral THC products).
CBD should be used according to the manufacturer’s instructions. Make sure you read and follow the label carefully. Only use the amount instructed. Using more may increase the chance of side effects, interactions, or other problems.
Studies looked at the use of cannabinoids (THC alone and CBD combined with THC) in people with chronic pain. In general, results showed improvements in pain measures, but they were not statistically significant.
CBD and Medicines/Drugs
As stated above, CBD is in a class of chemicals called cannabinoids. Because it comes from a plant, it is further classified as a phytocannabinoid.
The human body also produces natural cannabinoids, called endocannabinoids.
The dose of a CBD product depends on the form and strength, as well as the concentration of CBD in it. It’s also based on whether or not it has other active ingredients.
Medical cannabis users reported they used cannabis with higher CBD and lower THC concentrations for their insomnia. They also reported a decrease in the time required to fall asleep.
Both variations of cannabinoids act on cannabinoid receptors. These receptors are part of the complex endocannabinoid system (ECS). The system regulates the release of neurotransmitters (chemicals that communicate between nerve cells) in the brain, as well as in other parts of the nervous system. The ECS responds to both types of cannabinoids, phyto- and endo-.