The two main constituents of marijuana, THC and CBD, are known to be metabolized by the cytochrome P450 system, the major enzymes involved in drug metabolism. Specifically, studies have shown that CBD can inhibit:
Further adding to the potential benefit of CBD, is the fact that it is considered CBD is considered “non-euphoric”, even at high doses. In fact, many studies have shown that when combined with THC, CBD can decrease some unwanted effects, such as cognitive impairment.
Nevertheless, until more studies are completed, CBD should be used cautiously in those taking prescription medications. Below, we discuss CBD and potential drug interactions with trazodone and Effexor in more detail.
While THC (delta-9-tetrahydrocannabinol) is likely more well-known due to its psychoactive and euphoric effects, CBD makes up almost 40% of many cannabis extracts and has a wide range of potential benefits when used medicinally, although more studies are needed to better understand the compound.
What Is CBD (Cannibidiol)?
The amounts of CBD used in studies range greatly (from 1 mg to over 600 mg), but there is preliminary positive evidence for a variety of indications, including:
CBD has recently has exploded in popularity, with many different products available over the counter. With this, it is important to consider potential drug interactions with prescription medication, such as Effexor and trazodone.
Even then, we don’t know much about CBD in general. We do know that CBD can inhibit certain metabolizing enzymes, a common characteristic of many drug interactions. However, there are many studies that theorize that while CBD does inhibit metabolizing enzymes, it takes extraordinarily large doses to do so and the inhibition is not to a significant extent for most individuals.
Cannabidiol, also known as CBD, is a non-euphoric constituent of cannabis, also known as marijuana.
In our latest question and answer, the pharmacist discusses whether or not CBD (cannabidiol) interacts with trazodone or Effexor (venlafaxine).
At the same time, it’s important to be aware that CBD can interact with some medications. Taking it at the same time as other drugs can affect CBD’s dosage and effects, and can even change how your body breaks it down.
The CYP450 Pathway
That brings us to our list. Remember, the general rule is that you need to be careful taking CBD at the same time as any drug or medication that gets processed by CYP450 enzymes. If you’re thinking about doing so, be sure to check with your doctor first.
CBD and the CYP450 Pathway
This article is your guide to safely taking CBD alongside your other medications and supplements. First, it has a quick overview of how CBD interacts with other drugs in your body, and then it lists the most common drugs that interact with CBD, and which you should be careful about taking at the same time. If you want to skip ahead, you can find the list here.