Cannabidivarinic acid (CBDVA) is the acidic form of CBDV found in raw cannabis.
Interestingly, because hemp has less than 0.3% THC, it falls into a different legal category than marijuana. Specifically, it is no longer a Schedule I illegal substance. Because of this, it is legal to grow hemp plants and produce hemp-based products such as CBD, CBD oil, phytocannabinoid hemp oil, and other products that contain potentially beneficial phytocannabinoids without very much THC.
The ECS helps the body maintain functional balance through its three main components : “messenger” molecules that our bodies synthesize, the receptors these molecules bind to, and the enzymes that break them down. Pain, stress, appetite, energy metabolism, cardiovascular function, reward and motivation, reproduction, and sleep are just a few of the functions influenced by the endogenous cannabinoid system.
Everyone’s endocannabinoid system is unique. The rates of endocannabinoid production vary wildly, as do the number of cannabinoid receptors in our bodies. Prolonged use of cannabis causes the brain to reduce the number of CB1 receptors that are available for activation. Using human brain imaging, we can observe that just 48 hours of abstinence from cannabis is sufficient to resensitize the system and bring the expression of CB1 proteins to a level comparable to non-cannabis users.
Cannabidivarin (CBDV) is a relative of CBD; both derive from the cannabinoid precursor CBGVA. CBDV has been found to have anti-epileptic and anticonvulsant properties .
Chemotypes of cultivated varieties
These cannabinoids may be altered further through decarboxylation. When a chemical compound decarboxylates, it loses carbon atoms and releases carbon dioxide, either by heat or prolonged exposure to environmental stress. THCA and CBDA decarboxylate into THC and CBD, respectively, and only then do they exhibit psychoactive effects. THC, CBD, and other neutral cannabinoids can then be metabolized, or broken down into other cannabinoids by way of oxidation, or exposure to oxygen. CBD, for example, may be oxidized into the metabolites cannabielsoin (CBE) and cannabidinodiol (CBND).
In many ways, the defining feature of hemp, as opposed to marijuana, is that hemp plants do not produce very much THC. As such, phytocannabinoid-rich hemp plants don’t have the same concentrations of cannabinoids as other cannabis plants. But consuming all the phytocannabinoids together, rather than isolating components like CBD, produces an entourage, or ensemble, effect, increasing the medicinal potential of the plant. Marijuana also has its own entourage, or ensemble effect, with various cannabinoids acting together to enhance the plant’s effects.
Cannabinoids and how they work in our body
When phytocannabinoids are activated, or decarboxylated, of their 2-carboxylic acids by heat, light, or alkaline conditions, they then turn into neutral cannabinoids, generally referred to as simply “cannabinoids”.
The “A” at the end = 2-carboxylic acids
These cannabinoids are non-intoxicating except for THC: Δ 9 –tetrahydrocannabinol.
These phytocannabinoids found in the plant are in what is called their ‘acidic’ form. Some of the major acidic phytocannabinoids are:
Everyone these days is talking about the medicinal benefits of CBD.
Phyto = Pertaining to plants or plant-based.