CBD is metabolized by the liver, and large doses may lead to liver toxicity. Talk with your healthcare provider before using CBD. If you are on any prescription medications, they may recommend regularly monitoring your liver through bloodwork to ensure CBD is safe for you.
There are many different forms of CBD, and you may need to try different delivery methods before finding the one that is right for you.
How to Use CBD for Ulcerative Colitis
It’s important to talk with your healthcare provider before adding any supplemental therapy, such as CBD, to your ulcerative colitis treatment. They will be able to determine if CBD will be beneficial for your individual case and can recommend the right dosage.
CBD has many therapeutic properties and is a known anti-inflammatory, antimicrobial, and antioxidant. Thanks to its anti-inflammatory properties, CBD may be a potential therapeutic treatment for ulcerative colitis.
Shopping for CBD
Though CBD is generally well tolerated, you may experience some side effects. Common side effects include:
The marijuana plant Cannabis sativa and its derivatives, cannabinoids, have grown increasingly popular as a potential therapy for inflammatory bowel disease (IBD). Studies have shown that modulation of the endocannabinoid system, which regulates various functions in the body and has been shown to play a key role in the pathogenesis of IBD, has a therapeutic effect in mouse colitis. Epidemiologic data and human therapy studies reveal a possible role for cannabinoids in the symptomatic treatment of IBD, although it has yet to be determined in human populations whether cannabinoids have therapeutic anti-inflammatory effects in IBD or are simply masking its many debilitating symptoms. Large, double-blind, randomized, placebo-controlled trials using serial inflammatory markers, biopsy findings, and endoscopic disease severity to demonstrate objective improvement in IBD are necessary before cannabis can be empirically accepted and recommended as an IBD treatment option. Questions concerning its safety profile and adverse effects prompt the need for further research, particularly in regard to dosing and route of administration to maximize benefits and limit potential harms. Cannabis use should be reserved for symptomatic control in patients with severe IBD refractory to the currently available standard-of-care and complementary and alternative medicines.
The Endocannabinoid System and Its Role in Gastrointestinal Physiology
In CB2 -/- mouse models, the effect is similar, suggesting that these cannabinoid receptors together maintain intestinal homeostasis.
Increased Cannabis Use in Patients With Inflammatory Bowel Disease
CB1, cannabinoid 1 receptor; CB2, cannabinoid 2 receptor; DNBS, dinitrobenzene sulfonic acid; THC, tetrahydrocannabinol; TNBS, trinitrobenzene sulfonic acid; VDM11, N-(-4-hydroxy-2-methylphenyl) arachidonoyl amide.