CBD edibles might last a while, but they are not the hardest-hitting product available. Because CBD degrades in the strongly metabolic gut, you can expect a relatively low amount of CBD to reach your bloodstream when you eat it, with a bioavailability hovering around 6-20% ( 9 ).
The way you choose to consume CBD will alter how quickly you will feel its effects. Different consumption methods go through different biological systems with varying forces that impact how quickly CBD reaches your bloodstream to induce its effects.
CBD is best known for its potential health benefits. Research tells us that CBD holds significant health potential, with evidence that it may be able to improve the symptoms of anxiety, pain, sleep, and inflammation ( 1 , 2 , 3 , 4 ).
Inhaling CBD smoke or vapour will transport the cannabinoid’s effects to you quickly. This speedy delivery is because inhalation passes smoke and vapour through the lungs, which contain extremely permeable tissue that allow CBD to get to your bloodstream faster. With CBD inhalation you can expect to feel peak results as early as three minutes after consumption ( 10 ).
Method of consumption matters
We’ve gathered all you need to know about how CBD interacts with the body so that you can have a reasonable expectation of how long its effects will take to occur.
The researchers found that the maximum level of CBD in the blood was 14 times higher when consumed with the fatty breakfast than without. Overall, using CBD with food increased the amount of the cannabinoid in the body fourfold compared to using it in a fasted state.
Several factors influence the absorption rate, which is why a 2012 study by Schoedel and Harrison, published in Current Pharmaceutical Design, placed the bioavailability rate anywhere between 12% and 35%.
The rate of your body’s metabolism, known as the metabolic rate, involves breaking down and synthesizing compounds to help the body function properly. If you have a fast metabolism, it helps the body absorb CBD quicker.
When it comes to CBD absorption, size matters. A heavier individual may need more CBD to have the same effect as a lighter person who uses a lower dose. Reasons for this could be related to the strength of blood flow, fat stores, and more. While cannabidiol dosing guidelines are always broad, you’ll have to take into account your own body weight.
The mucous membranes have a porous layer covering minuscule blood vessels, allowing the oil to absorb into your bloodstream faster. It can work in five minutes, although most users report experiencing effects in 15-25 minutes.
A study published in the Journal of Clinical Pharmacology in 2019 analyzed the effect of cannabidiol on people with moderate to severe liver impairment. The researchers found that such individuals had greater blood CBD concentrations and lengthier clearance times after using 200mg of the cannabinoid than healthy control volunteers.
Not all CBD products are created equally. We see sellers championing cannabidiol extracted from organic hemp, which is the bare minimum one would expect! Low-grade cannabidiol not only contains a smaller amount of CBD but also may include ingredients that reduce bioavailability.