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The safest way to take CBD is orally, as a tablet, chewable, or tincture (a concentrated liquid typically administered with a dropper). Steer clear of any illegally sold synthetic CBD products, sometimes called “spice” or “bath salts.” These products have induced psychotic reactions in some people and pose a major health risk.
For adults, CBD appears to be a very safe product. CBD does produce side effects for some people, including nausea, fatigue, and irritability. It may also interact with certain medications, so always check with your doctor before use.
While CBD can come from marijuana, it can also be derived from hemp. Hemp is a related plant with 0.3% or less of THC. This plant is often used to make fabrics and ropes. As of 2018, Congress made hemp legal in all 50 states, and consequently CBD derived from hemp is also legal. The rules around marijuana-derived CBD, however, are far less clear.
CBD and other medications: Proceed with caution
Testing also shows that many products don’t contain what’s claimed on the label. For example, they may have less CBD than advertised. So, buyer beware.
Yes and no. Cannabidiol is one of the two best-known active compounds derived from the marijuana plant. The other is tetrahydrocannabinol, or THC, which is the substance that that produces the “high” from marijuana.
Currently, there is only one CBD product that has FDA approval: a prescription medication called Epidiolex, used to treat some rare severe seizure disorders in children. The bottom line is that in order to understand whether CBD is legal where you live, you’ll need to consult your state health department website or professionals in your community.
The endocannabinoid system: Essential and mysterious
Yes, there is evidence that CBD works for some conditions, but certainly not all the conditions it is being promoted for these days. There’s no evidence, for example, that CBD cures cancer. There is moderate evidence that CBD can improve sleep disorders, fibromyalgia pain, muscle spasticity related to multiple sclerosis, and anxiety.
But for children under age 21 it’s a different story. It’s also not clear if any amount of CBD is appropriate for children.
However, the endocannabinoid system can only regulate these areas when working properly. When this system fails, we see an increase in disease and disorders, like migraines, fibromyalgia, and IBS. Thanks to advances in medical science, we’ve discovered that when the body fails to produce enough of its own endocannabinoids, we may be able to supplement with plant cannabinoids.
What’s the Endocannabinoid System made Of?
But there’s a catch. As Elmes explains: “ THC and CBD can compete for anandamide uptake.” In other words, CBD and other cannabinoid “passengers” don’t get along.
CBD and the PPARS Receptor
There was an interesting study conducted on 2-AG that was published in The Journal of Sexual Medicine in 2017 by Dr. Sarah Biedermann, MD. In this study, they measured the blood serum levels of anandamide, 2-AG, and cortisol after self-stimulation in both men and women. They found that 2-AG increased during orgasm. However, all other chemicals measured including the “bliss” molecule anandamide, did not change.