This, in turn, builds a communication network that provides your body with biological feedback.
If you’re not used to cannabinoids such as CBD and THC, you may experience some initial changes in your hormones. However, as your endocannabinoid system gets accustomed to CBD, these hormones will eventually return to their normal levels.
Aromatase blockers are used to lower estrogen levels in cases of post-menopause and breast cancer. CBD can also speed up the breakdown of estrogen by acting on p450 enzymes in the liver.
Your body will naturally begin to slow its production of testosterone as you age, however low testosterone levels can impact your overall health. In fact, it can impact your body in a variety of surprising ways, including:
Indeed, CBD can actually help stimulate the production of testosterone and other ways. This cannabis compound has shown promise in limiting the production of prolactin and cortisolhormones, two neurotransmitters that can slow your level of production of testosterone. That’s because both these hormones are produced in your body in response to stress. Whether it’s physical or mental, lower testosterone levels are a natural response to stress.
Second, it’s important to remember that research is still being invested in the CBD and testosterone relationship. Most evidence now suggests that the use of CBD in your day-to-day activities will very likely not lead to an increase of testosterone in your body. However, it is suspected that the use of CBD does not have an adverse effect on your testosterone levels either. In fact, some would argue that the benefits that CBD has to offer may have a net positive benefit on your overall testosterone levels.
Within sperm cells, the pituitary gland, and your Leydig cells, you’ll find cannabinoid receptors that can have an impact on your testosterone production. So if some cannabinoids are bad for testosterone production, what does CBD do? There’s a body of evidence to suggest that CBD could play a role in balancing your testosterone levels. That’s because CBD has the potential to slow down the production of testosterone, while simultaneously limiting the breakdown of testosterone in the liver. Similarly, it does not lower the levels of circulating serum testosterone in the blood.
The ECS can play a role in your body’s ability to produce testosterone. That’s because your ECS and your hypothalamic-pituitary-adrenal axis interact with each other. Your HPA is the part of your body responsible for creating testosterone. In order for your body to produce testosterone, signals are to be sent from the brain and hypothalamus. From there, your pituitary gland activates the luteinizing hormone which leads to the production of testosterone from the Leydig cells.
Various water-insoluble cannabinoids as well as SP-111A, the water-soluble derivative of delta 9-tetrahydrocannabinol (delta 9-THC), reduced hCG and dibutyryl-cAMP stimulated testosterone production by rat testicular Leydig cell preparations. With 0.15 microM (0.05 micrograms/ml) 8-beta-OH-delta 9-THC the inhibition was about 50% of stimulated testosterone synthesis. Dose-related inhibitions were apparent with other cannabinoids and their order of potency in inhibiting stimulated steroidogenesis by the interstitial cells in vitro was found to be: 8-beta-OH-delta 9-THC greater than or equal to 11-OH-delta 9-THC greater than CBN = CBD = CBG greater than or equal delta 9-THC = delta 8-THC. The non-stimulated, basal, steroidogenesis was not affected even with 15 microM cannabinoids. The incorporation of L-[U-14C]leucine into the protein of Leydig cells was markedly reduced by 15 microM cannabinoids under both basal and stimulated conditions. The inhibition of steroidogenesis as well as protein synthesis in rat testicular Leydig cell preparations by various cannabinoids cannot be correlated with their psychoactivity. The present data suggest that cannabinoids at very low concentrations may interfere directly in Leydig cells with both protein and testosterone synthesis, and thus with their function.