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I walked in not knowing what to expect and was presently surprised! Relaxed atmosphere, really knowledgeable staff and all around welcoming space. Max and Noah gave me the 101 about their family business and their CBD products. I’m so excited to try them! Ended up buying oil for me and a gift for my mom! . ♀️ – Ana Taylor
I started taking the Canviva Sport 2500mg about a month ago and I have to say I am amazed! It has been over 20 years since I have slept soundly through the night (no joke) and ever since I started taking Caniva at night, I have been able to sleep through the night without waking up. Not only that, I wake up feeling rested. I feel great when I get up. It’s made with organic CBD. I didn’t actually anticipate such great results, as nothing has helped me sleep. I highly recommend. – Angela L’Esperance
CBD Health & Wellness LLC
Kevin at Your CBD Store is the absolute best and truly cares about your wellbeing. He’s not out there just to make a sale. Instead, he is passionate about helping others get their health back and find joy in life! – Jaron Faber
Significance: Administering CBD as a capsule rather than a liquid allows for more precise determination of pharmacokinetics parameters and is more representative of CBD swallowed products. The fat content of a meal can lead to significant increases in Cmax and AUC0-∞ and can account for variability in bioavailability and overall drug exposure within patients with oral products.
Methods: Adult patients who were prescribed CBD for seizures, had localization-related intractable epilepsy with ≥4 seizures per month, and qualified for Minnesota cannabis were enrolled. A single dose of 99% pure CBD capsules was taken under both fasting (no breakfast) and fed (high fat 840-860 calorie) conditions. Blood sampling for CBD plasma concentrations was performed under each condition between 0 and 72 hours post-dose and measured by a validated liquid chormatography-mass spectometry assay. CBD pharmacokinetic profiles including maximum concentration (Cmax ), area-under-the-curve from zero to infinity (AUC0-∞ ), and time-to-maximum concentration (Tmax ) were calculated. The confidence intervals (CIs) for log-transformed Cmax and AUC0-∞ ratios between fed and fasting states were calculated. Seizure and adverse events information was collected.
Objective: To evaluate the pharmacokinetics of a purified oral cannabidiol (CBD) capsule administered with and without food in adults with refractory epilepsy.
Results: Eight patients completed the study. On average Cmax was 14 times and AUC0-∞ 4 times higher in the fed state. The 90% CI for the ratio of fed versus fast conditions for Cmax and AUC0-∞ were 7.47-31.86 and 3.42-7.82, respectively. No sequence or period effect for Cmax and AUC0-∞ was observed. No adverse events were reported.
Keywords: CBD; cannabidiol; epilepsy; food-effect; pharmacokinetics.