cbd oil for high blood pressure

Cbd oil for high blood pressure

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Types of high blood pressure

While there have been data [4] that show that CBD can help relax arteries and veins, it is unclear whether CBD actually lowers blood pressure in humans.

Hypertension is defined as an elevated blood pressure in your body. This means if either number is higher than a certain range, you may have hypertension. For your systolic blood pressure, if the number is 130 or greater, you likely have a high blood pressure. For the diastolic pressure, if you have a number higher than 80, you may have high blood pressure. The higher the numbers, the more serious your condition. Blood pressure measurements are as follows:

A normal blood pressure [6] is usually less than 120 over 80 (< 120/80). The first number is the systolic blood pressure, which is how much pressure the blood vessels in your body measures when your heart is beating. This systolic number is almost always higher. The second number is your diastolic blood pressure, which is the blood pressure in the blood vessels between heartbeats, or at rest.

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Since products may vary in dosages and ingredients, side effects may vary. However, the FDA has approved one CBD derivative, Epidiolex [13] for certain types of epilepsies. Based on those clinical trials, CBD may contain side effects such as liver injury, sleepiness when taken with alcohol or other drugs, bigger appetite, and possibly diarrhea.

Cbd oil for high blood pressure

Compared with placebo, volunteers who had taken CBD had a lower TPR throughout and especially in the post–mental stress period ( Figure 3H ; P < 0.05 to < 0.0001). Volunteers who had taken CBD also reduced forearm skin blood flow before and during the latter part of mental stress ( Figure 3I ; P < 0.05 to < 0.01).

Upon arrival, subjects were rested for 10–15 minutes, and their baseline blood pressure and heart rate were recorded using a digital blood pressure (BP) monitor. Participants were given a standardized breakfast, and 15 minutes later, they were given either oral CBD (600 mg) or placebo in a double-blind fashion. This is a dose known to cause anxiolytic effects in humans and is comparable with what is used clinically (19, 37–39). Study medication consisted of capsules containing either 100 mg of CBD or excipients, which were a gift from GW Pharmaceuticals. There was no difference between the 2 formulations in color, taste, or smell.

Cold stress test.

The cold pressor test caused a significant rise in TPR (as expected) in the placebo group only ( Figure 5H ; P < 0.01) and rise in forearm skin blood flow with both CBD and placebo ( Figure 5I ; P < 0.05). The overall trend was for lower TPR and forearm skin blood flow in those who had taken CBD, with post-hoc analysis showing a reduction in both just before and in the latter half of cold stress ( Figure 5H [P < 0.05 to < 0.0001] and Figure 5I [P < 0.001]).

The mental arithmetic test consisted of calculating a sum every 2 second for 2 minutes. Subjects were seated in front of a computer screen, and a PowerPoint presentation delivered a slide with a simple mathematical sum of a 3-digit number minus a smaller number (e.g., 317 – 9, 212 – 11, 185 – 7) every 2 seconds; the subject had to give the answer verbally. In the isometric exercise stress test, using a dynamometer, handgrip was maintained at 30% of maximum voluntary contraction (MVC) for 2 min. For the cold pressor test, subjects immersed their left foot (up to ankle) in ice slush (temperature 4°C–6°C) for 2 minutes. Cardiovascular parameters were measured continuously using the Finometer, while skin blood flow measurements were taken just before, during, and 5 minutes after each test. Each stress test lasted for 2 minutes, and there was a recovery period of at least 10 minutes.

Study approval.

CBD treatment reduced resting systolic blood pressure (SBP) (mean difference –6 mmHg; 95% CI, –1 to –12, P < 0.05, Figure 1A ). Although there was no overall difference in diastolic blood pressure (DBP) and mean arterial blood pressure (MAP) between the 2 groups, post-hoc analysis showed that both DBP and MAP were lower with CBD treatment ( Figure 1, B and C , respectively; P < 0.01), particularly in the latter time points (120–160 min).