cbd oil dopamine

Cbd oil dopamine

Beyond its relationship with dopamine production, CBD acts in multiple ways on your brain. By acting on TRPV-1 receptors, it helps regulate body temperature, relieve inflammation and pain. Widely known for its positive action on chronic pain, CBD is also highly valued for its anti-epileptic and anti-anxiety properties. In fact, people suffering from epilepsy are increasingly using CBD to reduce the frequency and intensity of spasmodic disorders. In addition, CBD has antioxidant, analgesic, and neuroprotective properties that enhance its enormous therapeutic potential. The bottom line is that CBD is a natural substance that positively affects many receptors in our brain and body, and has yet to reveal the full extent of its powers.

The human brain is a complex organ that the scientific community has not yet mastered perfectly. As a result, it is still difficult to establish an official connection between cannabinoids and the human brain, although this hypothesis seems to be approved by the majority of researchers. In the 1960s, scientific studies revealed the existence of the endocannabinoid system: a system common to all vertebrates that interacts with cannabinoids. From this point on, it seems obvious that the body of humans and animals reacts to cannabis, and in particular to the CBD molecule. But what about dopamine production in the brain?

To date, there are no known side effects from taking CBD. Some people have already noticed a feeling of drowsiness or nausea, but these side effects are often related to the intake of another drug or a pathology that is not related to CBD. You can consume this natural substance without any danger to your health. If in doubt, don’t hesitate to ask your doctor for advice on the best dosage of CBD for you.

According to scientific research, CBD is indeed capable of promoting the production of dopamine in the brain. Even if the research on this subject is far from being completed, it would seem that CBD has a positive action on what is more commonly known as the “happiness hormone”.

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Can taking CBD cause side effects?

Scientific studies are clear on this subject: short-term drug use increases the level of dopamine, but affects it drastically in the long term. This is why people who use cocaine, for example, always want more and cannot do without it to feel happy. The brain becomes dependent on these drugs to release dopamine, and a vicious cycle sets in.

CBD (cannabidiol), on the other hand, has no addictive effect on the brain. Even if the CBD molecule temporarily increases your dopamine level, it does not affect it in the long term. It doesn’t make you addicted or prevent your brain from producing dopamine without it. Although THC (tetrahydrocannabinol) is considered a psychoactive and unhealthy drug, it is also not considered addictive, unlike alcohol.

Even if its role in the process of dopamine production is still unclear, CBD acts on the production of this hormone, it is a fact. It’s hard to know how and why, but CBD does enhance dopamine production. Thus, it promotes the feeling of happiness, pleasure and satisfaction. With this conclusion, you may be wondering: What is the difference between CBD and drugs that increase dopamine production and make you addicted? Indeed, millions of people around the world consume CBD, often for therapeutic or medical purposes. And yet, they do not suffer from any form of CBD addiction. Why not? Simply because CBD does not act like a drug.

What is dopamine?

To fully understand how CBD affects your brain, it’s important to understand the role of dopamine in your body. Often referred to as the “happy hormone,” dopamine is a hormone that directly affects feelings of pleasure and reward. For example, dopamine can be released during a meal, before going to sleep, during sex, etc. The brain equates all of these positive actions as a reward.

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Although CBD is not considered an addictive substance, it would still be responsible for an increase in dopamine, the hormone responsible for feelings of happiness and pleasure. So, could CBD cause a form of psychological addiction? How does CBD really work on your brain? What is the difference between CBD and THC consumption? What are the long-term effects of CBD? All the answers to these questions can be found in this article dedicated to CBD, the brain, and dopamine production.

Cbd oil dopamine

Apart from the virtue of medicinal properties, recent studies on chronic cannabis inhalation reported the intimation of cerebrovascular diseases [7] although the underlying mechanisms have not been strongly established yet. Numerous neurological disorders have been observed in discrete studies on cannabis exposure viz. cognitive dysfunction, behavioral complications, memory/attention deficiency, structural and functional variations in the brain [8,9,10,11]. About 100 cannabinoids are being reported to date [12], out of which Δ9- tetrahydrocannabinol (THC) (Fig. 1) and cannabidiol (CBD) (Fig. 2) are the principal components that are actively involved in brain DAergic alterations. THC is one of the major and principal psychoactive constituents of cannabis [13]. In contrast, CBD is an anxiolytic and antipsychotic cannabinoid compound that may help in inhibiting the effects of THC and other negative effects effectuated due to cannabis exposure [14,15,16]. The psychoactive properties of THC are responsible for cannabis addictive potential and alterations in brain dopaminergic (DAergic) functions. Acute THC administration has been reported to elicit striatal dopamine (DA) release in animals [17] and humans [18,19,20].

Graphic Abstract

Drug or cannabis addiction is a compulsive drug intake disorder, embodied due to loss of control over drug intake limitation and when prevented, emerges a negative emotional state [21]. THC is the principal causative cannabinoid responsible for cannabis addiction due to its psychoactive properties and associated effects on brain DAergic function. Koob and Volkow [21] described three stages of drug addiction that confer major alterations in neurocircuits. The three stages are—(a) the binge/intoxication stage generated by changes in basal ganglia characterized by excess impulsivity and irresistibility to drug usage despite the detrimental effects associated with it, (b) the withdrawal/negative affect stage driven by changes in the extended amygdala involving stria terminalis that implies reward cognition due to the loss of motivations towards non-drug rewards, (c) the preoccupation/anticipation stage driven by alterations in the prefrontal cortex (PFC) involving disrupted GABAergic and glutamatergic activity (Fig. 3).

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Cannabis Addiction

The first study on CBD induced anxiolytic and antipsychotic effects was demonstrated in the 1970s and 1980s and was later studied in humans executing promising results [70]. In addition to anxiety and psychotic effects, basic and clinical research on other therapeutic contributions of CBD was conducted. Moreover, synthetic analogs of CBD with efficacious potentiality have recently been developed recommended for patients with compromised health [71]. CBD was first isolated from cannabis extracts by Adams and his co-workers in the year 1940 [72]. In the early 1970s, several studies reported that CBD was incompetent to imitate the effects of cannabis, which led to hypothesize that; CBD would be a non-functioning cannabinoid. However, it was also speculated that CBD, with other cannabinoids, could interfere with the THC effects [73, 74]. These studies indicated the pharmacological activities of CBD exhibiting a broad spectrum of gesture [70].