cbd oil cancer dosage dogs

1. Henry, J. G., Shoemaker, G., Prieto, J. M., Hannon, M. B., & Wakshlag, J. J. (2020). The effect of cannabidiol on canine neoplastic cell proliferation and mitogen-activated protein kinase activation during autophagy and apoptosis. Veterinary and Comparative Oncology, e12669, e12669. https://doi.org/10.1111/vco.12669

This study documents the anti-cancer effects of CBD alone and in combination with chemotherapy drugs. It also provides hints as to the mechanisms and pathways that CBD influences in canine cancer cells. Additional study is needed to better understand these mechanisms and define safe and effective dosages for dogs. Whether CBD is used as a primary treatment or to manage the side effects of chemotherapy, additional knowledge will allow for safer and more effective use. CHF and its donors remain committed to exploring new and better treatments for canine cancer, like CBD. Learn more about our cancer research at akcchf.org/oncologyRPA.

Cannabidiol (CBD) is one of many chemicals identified in the Cannabis sativa plant, commonly known as hemp. It has been used for palliative care in oncology, but recent studies in humans and rodent models show that it may have direct anti-cancer effects. Since there is little data on the effects of CBD in canine cancer, investigators at Cornell University are studying what happens to canine cancer cells when they are exposed to CBD alone or in combination with common chemotherapy drugs (AKC Canine Health Foundation (CHF) Grant 02643-A: Examination of the Effects of Cannabidiol on Canine Neoplastic Cell Apoptosis/Autophagy and Potential for Chemotherapy Resistance or Sensitivity). Results were recently published in Veterinary and Comparative Oncology 1 and offer hope for canine cancer patients.

Help Future Generations of Dogs

Cell cultures from different canine cancers (osteosarcoma, mammary carcinoma, and lymphoma) were exposed to various concentrations of CBD alone and in combination with the common chemotherapy drugs doxorubicin and vincristine. CBD oil caused a significant decrease in cancer cell reproduction in all cell lines studied. Use of CBD-rich whole help extract was able to reduce cancer cell reproduction at lower concentrations than CBD oil alone. This is likely due to the ‘entourage effect’ where the mixture of numerous chemicals seems to work in concert to produce a greater effect. The phenomenon needs more study though, since different cancers have different receptors for these chemicals and not all cultured hemp plants contain the same amounts of these chemicals. CBD in combination with the chemotherapy drug vincristine also decreased cancer cell reproduction in a synergistic way – or with greater effect than either chemical alone. When CBD was combined with doxorubicin, the results varied depending on the concentration of each chemical used.

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

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Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Cbd oil cancer dosage dogs

While many humans with cancer turn to medical marijuana, it’s important to know that the THC in marijuana is toxic to dogs, so it’s crucial to choose CBD with less than 0.3% THC. Quality pet CBD from a reputable source will be made from the hemp cannabis Sativa plant, which is naturally high in cannabinoids, but has almost no THC and is legal in all states.

Make sure you buy CBD from a reputable company that conducts and shares third-party lab test results. Review these materials to be sure that the CBD you’re offering your dog contains the stated amount of CBD, 0.3% THC or less, and is free from pesticides and heavy metals so you can be sure you’re giving your pup the best opportunity for natural relief with hemp CBD.

Pet CBD is not the same as medical marijuana

CBD isolate for dogs with cancer: At the other end of the spectrum is CBD isolate, which is pure CBD and the most refined option. It contains no plant matter, so it has no flavor, making it a good choice for the pickiest pets. Some people choose isolates because they are pure CBD and they contain no THC.

Pain and inflammation can be side effects of cancer treatment or a symptom of the progression of the disease itself. Pain management is almost always a crucial part of how to treat cancer in dogs. You will want to ask your veterinarian about adding CBD to your pain management plan, but it can be a way to add another layer of relief, naturally and without side effects.

Are there other natural supplements for dogs with cancer?

Broad-spectrum CBD for dogs: Broad-spectrum CBD is the middle ground; it still contains just enough plant material and terpenes for an entourage effect but has a mild taste. Both the full-spectrum and distillate options have virtually no THC (less than 0.3%) and the CBD isolate lacks THC completely, making all options non-psychoactive.