cbd memory impairment

Cbd memory impairment

In addition to the aforementioned publications, an additional study suggests that CBD may be a promising treatment for people recovering from addiction due to its effect on memory (8).

Patients with Alzheimer’s disease experience progressive cognitive decline due to the degeneration of neurons in the brain, which further destroys neural pathways. Numerous studies have shown that CBD oil not only prevents the destruction of these neurons, but it also aids the body in creating new ones (neurogenesis). (2)

CBD, Memory, and Addiction

That’s the backfiring selectivity of your memory.

In simple words, the study concludes that CBD can help with addiction by altering memories linked to substance use.

CBD for Memory Loss Caused by Stress and Anxiety

In recent years, CBD has been found to alleviate certain symptoms of memory loss conditions, including different types of dementia. People are turning to CBD oil to treat Alzheimer’s disease as well as to improve focus and enhance the daily performance of their brains.

Clinical and preclinical evidence has indicated that estrogen depletion leads to memory impairments and increases the susceptibility to neural damage. Here, we have sought to investigate the effects of Cannabidiol (CBD) a non-psychotomimetic compound from Cannabis sativa, on memory deficits induced by estrogen depletion in rats, and its underlying mechanisms. Adult rats were subjected to bilateral ovariectomy, an established estrogen depletion model in rodents, or sham surgery and allowed to recover for three weeks. After that, they received daily injections of CBD (10 mg/kg) for fourteen days. Rats were tested in the inhibitory avoidance task, a type of emotionally-motivated memory. After behavioral testing they were euthanized, and their hippocampi were isolated for analysis of components of the Akt/GSK3β survival pathway and the antiapoptotic protein Bcl2. Results revealed that ovariectomy impaired avoidance memory, and CBD was able to completely reverse estrogen depletion-induced memory impairment. Ovariectomy also reduced Akt/GSK3β pathway’s activation by decreasing the phosphorylation levels of Akt and GSK3β and Bcl2 levels, which were ameliorated by CBD. The present results indicate that CBD leads to a functional recovery accompanied by the Akt/GSK3β survival pathway’s activation, supporting its potential as a treatment for estrogen decline-induced deterioration of neural functioning and maintenance.

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Keywords: Cannabidiol; Estrogens; Memory; Neuroprotection; Ovariectomy.