Also, just one of four studies in which cannabidiol (CBD) was administered concurrently with THC found CBD administration reduced these symptoms, they wrote in the Lancet Psychiatry.
— Evidence suggested adding CBD does not ameliorate these effects
Hjorthøj and Posselt cautioned against extrapolating these findings to assume “single doses of THC will eventually lead to schizophrenia,” but also emphasized that “caution should not be thrown to the wind.”
The psychoactive components of cannabis were linked to new-onset psychotic symptoms even at low doses, according to a systematic review and meta-analysis.
“The endocannabinoid system is critical for neurodevelopment and as such is present in early development, and maintains expression throughout life.” 9 Numerous important changes take place in the brain during adolescence; in particular, neuronal maturation and rearrangement processes (eg, myelination, synaptic pruning, and dendritic plasticity). 21
Cannabis consists of numerous compounds, but the central 2 are cannabidiol (CBD) and Δ-tetrahydrocannabinol (THC), which is responsible for the psychoactive effects that occur via its interaction with the endocannabinoid system. 9 Adolescents typically do not think that cannabis use is as risky as other substances, a belief that has been “steadily growing.” 1 When asked, “How much do you think people risk harming themselves if they smoke marijuana regularly?” less than one-third of high school seniors responded that there was a “great risk” in 2016 compared with 58% in 2006. 1 The pervasiveness of cannabis, together with its “relatively low lethality,” has led to the misperception among adolescents and adults alike that it is innocuous 9 ; for example, many baby boomers who used cannabis when they were in college have resumed use. 10 However, the amount of THC is considerably higher than it was in the 1960s and 1970s, with rates that continue to climb. THC levels in cannabis have risen from 8.9% in 2008 to 17.1% in 2017, and the mean THC:CBT ratio also rose substantially, going from 23 in 2008 to 104 in 2017. 11