cbd gaba receptors

3. Campos AC, Moreira FA, Gomes FV, Del bel EA, Guimarães FS. Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders. Philos Trans R Soc Lond, B, Biol Sci. 2012;367(1607):3364-78.

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2. Pertwee RG. The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. Br J Pharmacol. 2008;153(2):199-215.

Topic: Comprehensive Neurotransmitter Primer

September 4, 2019

Phytocannabinoids are plant-derived compounds that interact with the endocannabinoid system in humans and other animals. There are over 100 known phytocannabinoids, with CBD being the most abundant in the cannabis plant. The endocannabinoid system in humans has two primary receptors: CB1 and CB2. The endogenous cannabinoid, anandamide, and its phytocannabinoid equivalent, THC, mostly interact with the CB1 receptor, while the endogenous cannabinoid 2 – arachidonoylglycerol and its phytocannabinoid equivalent, CBD, interact with both CB1 and CB2 receptors, among others.

September 16-20, 2019


Earn up to 14.5 CME credits!

Are you curious about your patient’s neurotransmitter levels? Whether you have clinically recommended CBD or your patients are self-supplementing, the NeuroBasic Profile (serotonin, GABA, dopamine, norepinephrine, epinephrine, glutamate, histamine, glycine, and PEA) can illuminate neurotransmitter levels reflective of potential CBD influence.

Wellness Wednesday

Cbd gaba receptors

You could also naturally increase your GABA levels by meditating daily, doing yoga, or listening to Morgan Freeman gently narrate an audiobook. Probably.

Let’s put it this way: high levels of GABA feel like having young Khalid croon you to sleep, until glutamate levels kicks the door down and puts on Wake Me Up by Avicii.

The natural extracts of CBD are able to boost GABA. With increased GABA levels, your brain’s GABA receptors can organically reduce the amount of signals your brain receives, relieving your brain of mental activity and making you feel calmer. In other words, CBD will help us relax more, relieve tension, and sleep deeper.

Once the alcohol enters your bloodstream and is processed through your liver, the disruption in your brain is caused by the alcohol trying to mimic gamma aminobutyric acid (GABA). Increased GABA levels reduce your neural activity. This is why you’re able to fall into a blissful slumber in the first half of the night.

In contrast, using CBD products can actually raise GABA levels naturally.

First off, the stigma against cannabis is long gone. The unveiling of marijuana’s benefits has galvanized more and more states—including the country’s capital—to decriminalize or legalize the medical and recreational use of cannabis.

If you crave uninterrupted sleep, try replacing that glass of whiskey with cannabis. Before you gasp, shudder, and refuse to associate yourself with illegal drugs, let’s consider the facts:

CBD is the non-psychoactive component of marijuana that affects the body, rather than the mind, unlike its counterpart tetrahydrocannabinol (THC) which is what gives you the distinctive high that marijuana is notoriously known for.

“Contrary to popular opinion, consuming alcohol can actually interrupt your sleep rather than improving it.”

With wellness trends changing quicker than Kanye West’s fans, it’s difficult to keep up with what works and what doesn’t. But passing the Farm Bill in 2018 marked an important milestone for the CBD industry because implementing regulations actually helped weed out (pun intended) the shady proprietors from the legitimate businesses.

Ah, the humble nightcap—often disguised as an innocent invitation into your date’s home, or an unexpected signifier that the night, in fact, will continue. But have you ever had one too many drinks before stumbling into bed, hoping to fall into a deep slumber, only to be jolted awake in the middle of the night without knowing why?