CBD is available in many forms; topical creams and gels have shown promising results for inflammation and neuropathy, which may make them a good option for back and neck pain. 2
What Is CBD?
The cannabis sativa plant has two main varieties that are grown for specific purposes:
Ways CBD Treats Back Pain
Research indicates that CBD may reduce back pain by:
Animals were sacrificed by CO2 inhalation 15 days after the disc puncture. IVDs were removed, fixed in buffered 4% PFA for 24 hours and then subjected to the decalcification process in an ETDA solution consisting of 12% hydrochloric acid, 0.07% EDTA, 0.014% sodium tartrate, 0.8% sodium and potassium tartrate, in water, during 24 hours. After descaling, IVDs were dehydrated, embedded in paraffin and 5 µm sections were obtained with a microtome (Leica RM2145). The sections were then stained with hematoxylin and eosin for histological score and graded by an observer blind to the treatment conditions using the definition established by Norcross et al. 2003 , with some modifications ( Table 1 ), under a light microscope (Leica, Germany) at 5× magnification. A grade score ranged from 1 (several degenerated disc) to 5 (normal disc) was assigned separately to both AF and NP.
Fig. 2 shows the typical morphology of the intact IVD, which presents an AF with well-organized fibers and a clearly defined border. The NP comprises a significant disc area in the sagittal sections with minimal disruption in its border. Clear histological changes can be observed in the IVD after lesion with the needle puncture. Disc sections showed an AF with lamellar disorganization/fragmentation. NP presented complete obliteration of its cavity with fibrous material. Also, there is a significant decrease of the IVD height.
Intradiscal Injection of CBD or vehicle
Intervertebral disc (IVD) degeneration is believed to be the main contributor agent for chronic low back pain. It is a major public health problem with great socioeconomic impact worldwide. IVD degeneration is a multifactorial process characterized by serial progressive changes in the morphology, biochemical components and biomechanical function of the IVD , .
MRI is a non-invasive technique that is the most important method for clinical assessment of IVD pathology. The signal loss on T2-weighted MRIs correlates with the progressive degenerative changes of the IVD , . The brightness of the NP has been shown to directly correlate with proteoglycan concentration , even more than gross tissue morphology . Higher proteoglycan content in the NP induces water accumulation and increases MRI signal. This region is most severely affected during disc degeneration and, consequently, is a focus for novel cell-based regenerative strategies . However, the 30-gauge needle used for vehicle injection induced significant changes in MRI pixel intensity of the non-puncture discs. Therefore this methodology must be used with considerable caution.
The primary objective of this study was to investigate the ability of CBD to decrease degenerative events induced by needle puncture of the IVD. Three concentrations of CBD were injected into the IVDs immediately after the disc puncture.