Results: CBD-treated NOD mice developed T1D later and showed significantly reduced leukocyte activation and increased FCD in the pancreatic microcirculation.
Conclusions: Experimental CBD treatment reduced markers of inflammation in the microcirculation of the pancreas studied by intravital microscopy.
Background: Destruction of the insulin-producing beta cells in type 1 diabetes (T1D) is induced by invasion of immune cells causing pancreatic inflammation. Cannabidiol (CBD), a phytocannabinoid, derived from the plant, Cannabis sativa, was shown to lower the incidence of diabetes in non-obese diabetic (NOD) mice, an animal model of spontaneous T1D development.
Methods: Seven-week-old female NOD mice were prophylactically administered daily 5 mg/kg CBD or control vehicle i.p. five times weekly for ten weeks. Animals underwent IVM following confirmation of T1D diagnosis by blood glucose testing. Leukocyte activation and functional capillary density (FCD) were quantified via IVM.
Objective: The goal of this study was to investigate the impact of experimental CBD treatment on early pancreatic inflammation in T1D by intravital microscopy (IVM) in NOD mice.
Keywords: Type 1 diabetes; adhesion molecules; cytokines; functional capillary density; inflammation; intravital microscopy; leukocyte adherence.
While CBD could potentially have promise in controlling blood sugar levels and may even help prevent diabetes, the research is preliminary. Healthcare providers don’t fully understand the benefits or the drawbacks of CBD for most conditions, including diabetes.
When selecting a CBD product, you’ll have to choose between:
One study found that only about one-third of CBD products sold online were labeled correctly and that more than 20% of the CBD products contained THC as well.
In turn, that can reduce the symptoms of:
Do THC Levels in CBD Show Up on Drug Tests?
A 2020 medical review found that CBD has the potential to affect a number of factors that contribute to the development of insulin resistance, type 2 diabetes, and metabolic syndrome. These include the potential to reduce inflammation and alter glucose metabolism.
Some common forms of CBD are:
Finally, CBD can have interactions with over-the-counter (OTC) and prescription drugs. It's important not to underestimate the risk of CBD, especially if you're taking other medications or supplements.
What to Look For
Because there is limited research on CBD, scientists don’t fully understand the side effects of the compound. However, it’s believed that using CBD can cause:
When combined with a THC-based compound (the chief intoxicant in cannabis), CBD helped people with type 2 diabetes better control their blood sugar levels, according to a 2016 study that looked at blood sugar levels when fasting.