Helping people naturally is what CBD is all about. “We are definitely seeing a huge shift away from pharmaceuticals,” he says.
Former New York resident Cory Gleichenhaus, 42, grew tired of the harsh winters, and relocated to Florida for the warmth and palm trees. Last week, he opened a CBD American Shaman store in Delray Beach. Not surprisingly, many of his customers are senior citizens, who, like him, became full-time snowbirds, à la “Seinfeld migration.”
While physicians are not yet fully aware of what causes Tourette’s, other than the fact that it stems from a neurological issue, taking CBD is a multifaceted approach to helping the body and the mind. An added bonus, her son is achieving a deeper REM sleep, so his brain is potentially being purged of toxins.
“Our older customers are generally more cautious and skeptical,” he says. “They are worried, ‘Is this marijuana?’ No. ‘Is this legal?’ Yes. Education is a big part of our ethos. We are happy to answer any questions. We have a lot of samples on display that we encourage people to try and experience first hand.”
“One of our first customers was a lady in her 50s who has Parkinson’s disease. When she came in, she couldn’t control her head. I gave her a stronger product called ‘Equine,’ that was originally formulated for horses. It is a 900mg water-soluble CBD. By the time she left the store, her head was shaking slightly but she was no longer having such serious tremors. We all know there is growing anecdotal evidence about the efficacy of CBD, but when you see it with your own eyes, it makes a lasting impact,” says Gleichenhaus.
Significant limitations with the currently available antidepressant treatment strategies have inspired research on finding new and more efficient drugs to treat depression. Cannabidiol (CBD) is a non-psychotomimetic component of Cannabis sativa, and emerges in this regard as a promising compound. In 2010, we were the first laboratory to demonstrate that CBD is effective in animal models of predictive of antidepressant effect, a finding now confirmed by several other groups. Recent evidence suggests that CBD promotes both a rapid and a sustained antidepressant effect in animal models. CBD has a complex pharmacology, with the ability to interact with multiple neurotransmitter systems involved in depression, including the serotonergic, glutamatergic, and endocannabinoid systems. Moreover, CBD induces cellular and molecular changes in brain regions related to depression neurobiology, such as increased Brain Derived Neurotrophic Factor (BDNF) levels and synaptogenesis in the medial prefrontal cortex, as well as it increases neurogenesis in the hippocampus. This review presents a comprehensive critical overview of the current literature related to the antidepressant effects of CBD, with focus at the possible mechanisms. Finally, challenges and perspectives for future research are discussed.
Keywords: Antidepressant; BDNF; Cannabidiol; Depression; Neurochemical; Neuroplasticity.