can cbd penetrate skin

Can cbd penetrate skin

Meanwhile, Bugailiskis "absolutely" believes that however you ingest CBD can benefit your skin. For patients with chronic skin conditions like eczema or psoriasis, Bugailiskis often recommends a CBD sublingual tincture (which can be taken under the tongue) twice daily.

According to Schroder, when you apply CBD topically, it does not necessarily reach your bloodstream, but can be absorbed by the receptors in your skin and can work relatively quickly to treat the area where you’ve applied your product. (In order for CBD to penetrate your skin and go into your blood, you would need to be use a transdermal CBD product, like a patch or a gel specifically made to do just that.)

If you’re looking for a lightweight oil to add a little extra moisture, hemp oil is generally a more affordable way to get those benefits than CBD. However, if you want an oil that’ll calm irritated skin or combat acne the experts Bustle spoke to believe CBD would be more effective and therefore, the better choice.

Can you get high from using a CBD skin care ingredient?

"There are high costs involved in cultivating quality cannabis, deriving CBD from cannabis, testing the oils and then manufacturing and distributing the products; and these costs are translated into the final retail prices. The industry is still incredibly young so continued growth will likely lead to a natural stabilization of the numbers," argues Pamela Hadfield, co-founder of HelloMD.

Not all CBD beauty products are created equally. There are differences in the kind of CBD being used, and it’s extremely important to understand the distinction, says Meredith Schroeder, co-founder of Fleur Marché. "This is something we really try to clarify in our product descriptions. While making the distinction between isolate and full spectrum is perhaps more obvious, defining broad spectrum can be murky," she explains. Here’s how each are defined.

Can ingesting CBD affect your skin?

Broad Spectrum: Cannabis extract with all cannabinoids, minus trace amounts of THC. In this extraction process, the THC has been removed or other cannabinoids have been added back in with a CBD isolate. Schroeder explains that broad spectrum "still delivers ‘The Entourage Effect’ by using multiple parts of the plant," but does not contain any THC. Charlotte Palermino, co-founder of Nice Paper, an online platform that aims to educate people about cannabis and destigmatize weed, adds that while there is little research as to whether THC makes CBD more efficacious, it could potentially help.

Palermino doesn’t quite understand why anyone would put CBD in something like eyeshadow, and wants to remind consumers that if a makeup product claims to have cannabis, it can often just be hemp seed oil ("which is great for your lashes [and skin], by the way," she adds).

So, can CBD get across the skin and into the blood? Yes. A much more important question is whether it can reach an adequate level in the blood in order to affect your brain function. Once the CBD is absorbed into the blood it will distribute first to the body fat. Thus, for the majority of big adults who carry extra body fat, the amount of CBD that gets into the blood will be quickly absorbed into the fat and not the brain. Therefore, you may need to apply a lot of gel.

Casares L et al (2020) Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1 REDOX BIOLOGY, vol 28, Article No: UNSP 101321

Topical application of CBD may be more beneficial than smoking.

© Gary L. Wenk, Ph.D. is the author of Your Brain on Food, (3rd Edition, 2019; Oxford University Press) and is a member of the Governor’s Medical Marijuana Advisory Committee for the State of Ohio.

Posted February 13, 2020


Humans have been rubbing oily extracts of the cannabis plant into our skin for a very long time. The plant is mentioned several times (as “kaneh-bosem,”) in the Old Testament (as per Yahweh’s instruction to Moses in Exodus 30:23) as an ingredient in holy anointing oil. At that time in history, the word messiah simply meant “the anointed one.” Even if this reference is not historically accurate, marijuana was an important medicinal plant to our ancestors.

The three -dimensional cultured skin s ( EpiSkin ) were plated in the wells of the 12 well plates and conditioned overnight in maintenance medium. The maintenance medium was replaced with 2 mL of 1% Tween in PBS ( -) solution for each well, and 0.15 mL of the test sample was applied to the stratum corneum of the skin model and incubated at 37 ° C for 1, 3, 6, or 24 hours. At each time point, the test sample was removed fr om the surface of the skin and washed five times with 0.5 mL of the respective carrier oil .

This study demonstrates that Neossance S qualane greatly enhances CBD penetration into the epidermis . Delivery is critical to CBD product effectiveness as cannabinoid s receptors are located with in the epidermis . Neossance Squalane is proved to enable immediate penetration and, overall, deliver 1 0 to 40 times more CBD to the epidermis than sunflower oil, hemp seed oil, CCT, and jojoba oil over a 24-hour period.


The amount of CBD measured in the skin cell fraction of the model at various time points for each carrier oil is shown in Figure 1. Neossance Squalane facilitated faster and greater penetration and delivery of CBD into the skin over the 24 hour period of the experiment. In contrast, all of the other carrier oils demonstrated much lower penetration rates of CBD over the same time perio d. The amount of CBD delivered for each carrier oil is prov i ded in Table 1 , along with the percent of CBD delivered compared to Neossance Squalane at the 24 hour time point .

Cannabidiol (CBD) use in cosmetics and personal care has increased significantly since 2017. In order for topical products containing CBD to be effective, they must deliver CBD to th e receptors located in the epidermis . Delivery of CBD to the epidermis is determined by the carrier oils used . An in-vitro skin model was used to assess the penetration of 1% CBD in five carrier oils : Neossance ® S qualane , sunflower oil , hemp seed oil, caprylic / capric triglyceride s ( C CT ) , and jojoba oil. The amount of CBD in the epidermis was measured by HPLC at 4 time points : 1, 3, 6, and 24 hours. Neossance Squalane delivere d the most CBD into the epidermis across all time points , whereas CCT delivered the least.


The ability of carrier oils to facilitate skin penetration of CBD was evaluated using an in -v itro model of human skin. A commercially available in vitro reconstructed human epidermis from normal human keratinocytes ( E piSkin TM ) was used according to the manufacture r ’s instructions .