can cbd help with essential tremors

Can cbd help with essential tremors

CBD oil is administered under the tongue. From there, it absorbs through tiny blood vessels in the mouth, reaching the bloodstream. The effects of CBD oil are usually noticeable within 15-30 minutes after administration, lasting for up to 6 hours. The peak concentration levels of CBD oil are usually reached after 1.5 hours. The bioavailability of CBD oil is around 35%, meaning that slightly over one-third of the ingested content ends up in your system.

With CBD capsules , the route of administration causes a delay in effects. Since CBD needs to pass through the digestive system, the effects may need about 30 to 90 minutes to take hold, depending on your metabolism and whether you take CBD on a full or empty stomach. While CBD capsules offer lower bioavailability — up to 20% — they last longer than oils because CBD is released gradually from the liver.

You can also choose CBD isolate, which is pure CBD that has been crystallized and infused into the same product formats as the other types of CBD. The advantage of CBD isolates over other types of CBD oils is the lack of flavor and aroma; that being said, there’s also an obvious downside — the lack of entourage effect.

CBD’s potential in reducing different types of tremors is, without a doubt, promising. Several studies have already shown that it has the ability to improve primary motor symptoms of neurological conditions such as Parkinson’s Disease.

CBD Oil vs. Capsules for Essential Tremors

Tremors are involuntary movements of the body and can impact the hands, arms, head, face, legs, and voice. More often than not, tremors are caused by neurological disorders in the brain regions that control movement. Conditions that destroy or degrade the brain cells, like Alzheimer’s disease, Parkinson’s disease, or stroke, can trigger tremors.

Tremor sufferers can also adjust their lifestyle to naturally improve their lives, mainly by exercising, reducing alcohol, practicing meditation, and avoiding caffeine.

Reference links:

CBD Oil Dosage for Tremors

Researchers have yet to find out how CBD affects tremors. CBD is widely studied for its ability to reduce the symptoms of movement disorders. So far, we know that CBD can reduce muscle spasms, convulsions, and tremors associated with conditions like epilepsy, Parkinson’s Disease (PD) , and Multiple Sclerosis (MS ). One study actually found that CBD reduced the intensity of tremors in patients with PD during their REM sleep stage.

These compounds create a unique synergy known as the entourage effect. This concept was brought up in 1988 and further elaborated on in 2011 by E.B. Russo, an esteemed neuroscientist and cannabis expert. In the entourage effect, the sum of all active ingredients in the plant is more potent therapeutically than each compound in isolation.

Can cbd help with essential tremors

Go to

Go to

Resource links provided by the National Library of Medicine

The U.S. Food and Drug Administration (FDA) has not approved cannabis as a treatment for any medical condition. However, the chemical components in cannabis are being studied. It is well known that certain chemicals in cannabis activate specific receptors throughout the body and these chemicals may be useful in treating neurological conditions, like ET. In this study, Dr. Handforth is looking at a specific chemical called Cannabidiol. Cannabidiol (CBD) is one of at least 113 active chemicals (also known as cannabinoids) identified in cannabis. However, CBD does not produce any intoxicating effects or alteration in mood. For years it was thought to be a benign and unimportant part of the plant. Now it is being investigated as a possible treatment option for ET.

In this study, Dr. Handforth aimed to show CBD can suppress tremor in animal models. If successful, it would offer justification for further study of CBD in humans. First, the study had to determine what effects CBD would have on mice impacted with harmaline–induced tremor. Then, if reduced, the team had to discover how CBD suppressed the tremor.

Principle Investigator: Adrian Handforth, MD

Testing a variety of doses, Dr. Handforth was able to note a robust suppression of tremor in the mice given CBD, without the animals showing any signs of impairment or sedation. Next, the team worked to discover what receptors in the brain might be involved in the noted effects. After looking at several options the information suggests that CBD activates the 5HT1a receptors to suppress tremor by activating the TRPV1 receptor.

Cannabidiol Anti-Tremor Action & Mechanisms – Conclusion

“People tend to think of medical marijuana as a single substance; a substance that may have beneficial effects but also causes mood- and mind-altering effects,” explains Dr. Adrian Handforth, Assistant Chief of Neurology at VA Greater Los Angeles Healthcare System in California, “But that is not the case at all. Actually, marijuana is made up of many related chemicals, called cannabinoids.”

Cannabis, also known as marijuana, has been used for medicinal purposes for thousands of years. However, by federal law, the possession of cannabis is illegal in the United States, except within approved research settings; however, a growing number of states, territories, and the District of Columbia have enacted laws to legalize its medical use.

An ET-specific medication would impact millions of people around the world who have this life-altering condition but who don’t respond to the medications that are currently available. An ET-specific medication would be a life-changer for millions of men, women and children today and for generations to come.

Dr. Handforth is the lead researcher of an upcoming IETF funded study that will explore the effects of a particular cannabinoid known as “CBD” (cannabidiol) on essential tremor. Unlike the well-known cannabinoid “THC” (tetrahydrocannabinol), which has mind- and mood-altering effects, CBD does not alter the mind, the emotions, or one’s judgment. Although its long-term safety remains to be thoroughly studied, CBD has already shown some promising initial results in the treatment of epilepsy, pain, anxiety, and other disorders. Dr. Handforth and his team will try to find out whether CBD can suppress essential tremor in an animal model. And if it does, he will take the next step and try to understand how it works.

This is exactly why the IETF is so pleased to support Dr. Handforth and this cutting-edge research with a nearly $20,000 grant. “The significance of this work is two-fold,” says Dr. Handforth. “First, finding that CBD suppresses tremor in an animal model may provide justification for a clinical trial of CBD for essential tremor in humans. Second and more importantly, if we can understand how CBD stops the tremor, what mechanisms are at work, then an ET-specific medication could be developed that would be better-tolerated and more effective than what it available today.”