A small study of 22 people with Parkinson’s found that taking cannabis helped improve pain . However, this study involved medical marijuana, which contains both CBD and THC in various ratios.
The only downside of CBDistillery’s products is that they’re not made with organic hemp. Nevertheless, it’s still one of the best companies in this price range, so if you’re shopping for CBD on a budget, this is a rock-solid supplier.
For moderate problems, you can use the higher potencies. These include 300 mg, 600 mg, and 1000 mg of CBD per bottle. The last potency is a standard option for users who already have some experience and their daily dose doesn’t exceed 30 mg.
Comparing CBD with Levodopa for Parkinson’s
It’s no wonder that people with Parkinson’s disease often seek alternative forms of treatment.
Marijuana is a Schedule 1 substance, and without definitive proof of efficacy and/or safety, it is not nationally approved for medical indications. However, pharmaceutical marijuana is legal in 29 states, Puerto Rico, Guam, and the District of Columbia. 1 Variations exist within the laws of these states/territories, with some states imposing restrictions on tetrahydrocannabinol (THC) content, while permitting higher concentration cannabidiol (CBD) products. Seventeen states have low-THC, high-CBD laws in effect. 1
Side effects vary in accordance to THC and CBD formulations, and they include fatigue, dizziness, nausea, xerostomia, anxiety, headache, visual changes, impaired cognition, cough, and/or palpitations. 10 Driving and operating potentially dangerous equipment is not recommended for 8 to 12 hours after ingestion. Cannabis products are contraindicated during pregnancy or lactation and for people with cardiac decompensation. 10 Marijuana is ill-advised for children or young adults until the brain is fully developed. 11 Smoking cannabis has its own inherent risks. Beyond neurodevelopmental concerns, cannabis also has unclear risk for cardiac dysfunction and psychiatric concerns, such as for the emergence of depression and/or psychosis.
Animal research substantiates evidence of anti-oxidant action by THC and CBD, which might provide neuroprotection against progressive degeneration of nigrostriatal dopaminergic neurons in patients with PD. 7 CB receptors upregulate in response to noxious stimuli to mitigate inflammatory damage. In animals, CB1 antagonists lowered bradykinesia, while CB1 agonists reduced tremor; however, these benefits have not been demonstrated in patients who exhibit PD signs and symptoms. 8 However, patient surveys report alleviation of non-motor symptoms, specifically depressed mood, fatigue, and memory impairments. 9 Additionally, there are anecdotal accounts of neurological efficacy at decreasing parkinsonian motor manifestations.
Cannabis is becoming increasingly popular in the United States. 1 Many states have approved recreational marijuana, and several others allow medical and/or additional usages. 1 Medical marijuana is prescribed for a variety of indications; now, it even has possible application for people with Parkinson’s disease (PD). Cannabis might provide relief at diminishing bradykinesia, stiffness, rigidity, and tremors.